Web26 Sep 2024 · identify Sec62 as a critical molecular component in maintenance and recovery of endoplasmic reticulum homeostasis; Interaction of ribosomes and Sec62 with the core … WebThe disul- fide linkage between Deg1-Sec62 and the Sec61 channel may strengthen the interaction of the Sec62 N-domain with a signal sequence-binding site within the channel. …
Translocon component Sec62 acts in endoplasmic reticulum
Web5 Aug 2024 · The signal sequence is flanked by two Sec62 transmembrane helices, the cytoplasmic N-terminal domain of Sec62 is more rigidly positioned, and the plug domain is relocated. We crystallized the Sec62 domain and mapped its interaction with the C-terminus of Sec63. Together, we obtained a near-complete and integrated model of the active Sec … Web21 Mar 2024 · The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC63 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation … dallastown intermediate school
SEC62 SGD
Web9 Nov 2024 · It suggests that Sec62 interacts with Sec61 rather weakly whereas it forms a relatively stable tetramer complex with Sec63, 31.5, and 23 kDa proteins. The 31.5 and 23 … Web29 Mar 2024 · Cross-linking data in mammalian cells suggested that interaction of ribosomes and Sec62 with Sec61 is mutually exclusive and that the SRP receptor plays a … Web4 Dec 2015 · Sec62 interacts with Sec61 in a ribosome-sensitive manner. We first compared the interaction profile of Sec61 with translocon-associated proteins in intact canine pancreatic rough microsomes (RMs), where >80% of translocons are engaged with ribosomes45, and microsomes stripped of ribosomes by puromycin-high salt treatment … dallastown intermediate school address