Designing materials to direct stem-cell fate
WebStem cells in contact with materials are able to sense their surface features, integrate extracellular matrix (ECM) protein cues through a signal transduction pathway, and … WebBiomaterials are rapidly being developed to display and deliver stem-cell-regulatory signals in a precise and near-physiological fashion, and serve as powerful artificial …
Designing materials to direct stem-cell fate
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WebNov 8, 2012 · It is well-known that stem cells are tightly regulated by a combination of physical and chemical factors from their complex extracellular surroundings; thus, … WebNov 8, 2012 · Biomaterials for controlling stem cell fate. Biomaterials for stem cells have become an important part of regenerative medicine because they can serve as a biomimetic platform for relevant biological studies. 3 Furthermore, these materials can ultimately be used as scaffolds for constructing artificial tissues or organs for clinical applications. To …
WebNov 1, 2009 · Designing 3D materials to control stem-cell fate in vitro. Whereas 2D approaches allow well-controlled analysis of the impact on stem cells of individual … WebMar 1, 2013 · The effect, on the stem cell fate, of the cooperation between the mechanical properties and the growth factor in the same microenvironment has not yet been investigated. ... Designing materials to direct stem-cell …
WebThe materials pipeline for biomaterials and tissue engineering applications is under continuous development. Specifically, there is great interest in the use of designed materials in the stem cell arena as materials can be …
WebFeb 2, 2024 · Most design strategies for fabricating stem cell-laden tissue engineered scaffolds can be classified into one of the two categories. The first approach, top-down, focuses on designing the extracellular environment to contain the appropriate signals for guiding the differentiation of stem cells towards the lineage of choice.
WebJan 12, 2010 · Controlling stem cell fate with material design Advances in our understanding of stem cell interactions with their environment are leading to the … chinese name for potstickersWebAs stem cells are a cornerstone of regenerative medicine, research efforts have been extensively focused on controlling their self-renewal and differentiation. It is well-known that stem cells are tightly regulated by a combination of physical and chemical factors from their complex extracellular surroundings; thus, conventional cell culture approaches based … chinese name for monkeyWebIt is well-known that stem cells are tightly regulated by a combination of physical and chemical factors from their complex extracellular surroundings; thus, conventional cell … grand prince hotel new takanawa breakfastWebNov 1, 2013 · However, in vivo cell fate is likely influenced by a combination of geometry, mechanics and ECM composition [21], [22]. Thus we reasoned that combining these cues would prove useful in designing materials that more closely emulate the in vivo microenvironment and “fine-tune” a desired differentiation outcome. chinese name for pandaWebNov 30, 2015 · The extracellular matrix, a microenvironment of proteins and polymers that surrounds and connects cells, impacts a range of cellular behaviors including differentiation. For about a decade, researchers have been able to direct the fate of stem cells by tuning the mechanical stiffness of synthetic microenvironments such as hydrogels. Stem cells ... chinese name for pigWebNov 27, 2012 · As stem cells are a cornerstone of regenerative medicine, research efforts have been extensively focused on controlling their self-renewal and differentiation. It is … grand prince hotel new takanawa phone numberWebNov 26, 2009 · Biomaterials are rapidly being developed to display and deliver stem-cell-regulatory signals in a precise and near-physiological fashion, and serve as powerful … chinese name for mike